Selective H1 Antihistamine agent
|(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl) ethoxy)acetic acid dichloride
|A White or almost white Crystalline Powder
|Freely soluble in water, practically insoluble in Acetone and in Methylene Chloride
|Appearance of Solution
|5% solution is clear and not more intensely colored than reference solution BY7
|Identification by IR Absorption
|The absorption maxima in the spectrum obtained with the sample should correspond in position and relative intensity to those in the spectrum obtained with that of standard.
|Identification by HPLC
|The retention of the major peak in the Chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation as obtained in the assay.
|Identification by Sulphate Test
|It responds to the test of Sulphate.
|pH (1 gm in 20 ml water)
|1.2 to 1.8
|Loss on Drying
|Not more than 0.5% w/w
|Not more than 0.2% w/w
|Relative Impurities(By HPLC)Any Individual ImpurityTotal Impurity
|Not more than 0.1%Not more than 0.3%
|95% should pass through #60 mesh sieve
|Assay (on dry basis)
|99% to 100.5% w/w as C21H23ClN2O3.2HCl